STRUCTURE AND EXPRESSION OF THE GENE FOR THE PROTHORACICOTROPIC HORMONE OF THE SILKMOTH BOMBYX-MORI

被引：25

作者：

ADACHIYAMADA, T

IWAMI, M

KATAOKA, H

SUZUKI, A

ISHIZAKI, H

机构：

[1] NAGOYA UNIV,SCH SCI,DEPT BIOL,CHIKUSA KU,NAGOYA 46401,JAPAN

[2] UNIV TOKYO,FAC AGR,DEPT AGR CHEM,TOKYO 113,JAPAN

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1994年 / 220卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1994.tb18665.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We cloned and characterized two allelic variants of the gene for the Bombyx mori prothoracicotropic hormone (PTTH), a homodimeric 30-kDa brain secretory protein. These PTTH genes contain five exons that encode a precursor protein consisting of 224 amino acid residues whose C-terminal 109 residues represent the PTTH subunit. The Bombyx haploid genome contains a single copy of the PTTH gene. The major site of PTTH expression is the brain but expression at a very low level occurs in the gut. One Bombyx brain at day 0 of the fifth larval instar contained 2.4-2.8 pg PTTH mRNA, and this amount did not change markedly during larval-pupal development.

引用

页码：633 / 643

页数：11

共 38 条

[21] STRUCTURE AND ORGANIZATION OF 4 CLUSTERED GENES THAT ENCODE BOMBYXIN, AN INSULIN-RELATED BRAIN SECRETORY PEPTIDE OF THE SILKMOTH BOMBYX-MORI [J].