DEFINITION AND MAPPING OF STSS AT STR AND RFLP LOCI IN XP11-XQ22

被引：21

作者：

BARKER, DF ^{[1
]}

FAIN, PR ^{[1
]}

机构：

[1] UNIV UTAH,SCH MED,DEPT MED INFORMAT,SALT LAKE CITY,UT 84108

来源：

GENOMICS | 1993年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0888-7543(05)80381-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New primer pair sequences specific for 25 loci in the Xp11-q22.1 region are described. Eighteen of the pairs span segments containing significant CA dinucleotide repeats, with 9 of these revealing polymorphisms of greater than 50% heterozygosity. Four of the CA-containing segments occur in probes previously reported to detect RFLPs, while the remaining 14 are from newly isolated clones. STSs were also developed for 7 other RFLP-only loci. All of these 25 STSs plus 11 other published STR markers have been fine-mapped with respect to chromosomal breakpoints, defining 15 subintervals in Xpll-Xq22. This map of 36 STSs, nearly all of which are associated with markers that are genetically mapped and/or highly polymorphic, will significantly aid efforts to construct a complete physical map of this region and to correlate it with the high-density genetic map. © 1993 Academic Press, Inc.

引用

页码：712 / 716

页数：5

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