REDUCTION OF COLLAGEN DEGRADATION IN EXPERIMENTAL GRANULATION-TISSUE BY VITAMIN-E AND SELENIUM

被引：33

作者：

ASMAN, B

WIJKANDER, P

HJERPE, A

机构：

[1] KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT PATHOL 2,S-14186 HUDDINGE,SWEDEN

[2] KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT PERIODONTOL,S-14186 HUDDINGE,SWEDEN

来源：

JOURNAL OF CLINICAL PERIODONTOLOGY | 1994年 / 21卷 / 01期

关键词：

COLLAGEN DEGRADATION; GRANULATION TISSUE; OXYGEN RADICALS; ANTIOXIDANTS; VITAMIN-E; SELENIUM;

D O I：

10.1111/j.1600-051X.1994.tb00275.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The importance of antioxidants in inflammatory tissues has been studied in vivo. Degradation of homologous H-3-collagen powder by experimental granulation tissue induced by cellulose sponges in the rat was monitored as the radioactivity excreted in urine. By administering pharmacological doses of both vitamin E and selenium subcutaneously and by injection into sponges implanted subcutaneously, this breakdown of collagen was reduced. Injections in the sponges also arrested the maturation of the granulation tissue. Vitamin E and selenium are potential inhibitors of the free oxygen radicals from phagocytic inflammatory cells. It is therefore suggested that these radicals may play a role in the collagen destruction by granulation tissues, as in periodontitis.

引用

页码：45 / 47

页数：3

共 9 条

[1] PERIPHERAL PMN CELLS IN JUVENILE PERIODONTITIS - INCREASED RELEASE OF ELASTASE AND OF OXYGEN RADICALS AFTER STIMULATION WITH OPSONIZED BACTERIA [J].