Cognitive, Immunologic, Virologic, Functional, and Demographic Predictors of Health-related Quality of Life in People Living with HIV

Background: With recent progress in the treatment of people living with HIV (PLWH) and increasing their survival, quality of life has received highly attention. In the present study, we aimed to investigate the cognitive, immunologic, virologic, functional, and demographic predictors of health-related quality of life in people living with HIV. Methods: The study sample was comprised of 67 HIV-infected individuals who were under treatment of anti-retroviral therapy (ART) in Imam Khomeini Hospital of Iran, Tehran in 2016. We used correlation and step-wise regression to data analysis using SPSS-22 software. Results: The findings of stepwise regression analysis showed that prospective/retrospective memory complaint and daily life functioning were predictors of health-related quality of life in PLWH [P < 0.001, F (2,64) = 18.90, R2 adj = 0.520]. The results also showed that CD4 cell count, viral load, gender, age, and education were not predictors of health-related quality of life in PLWH (P > 0.05). Conclusion: The present article showed that prospective/retrospective memory complaint was a strong predictor of health-related quality of life in PLWH. Daily life functioning was another predictor of health-related quality of life. Considering that people living with HIV live longer with this chronic illness, knowing factors related to HRQoL plays a prominent role in survival and well-being of PLWH.