A NEW REAGENT FOR THE CLEAVAGE OF FULLY PROTECTED PEPTIDES SYNTHESIZED ON 2-CHLOROTRITYL CHLORIDE RESIN

被引：136

作者：

BOLLHAGEN, R

SCHMIEDBERGER, M

BARLOS, K

GRELL, E

机构：

[1] MAX PLANCK INST BIOPHYS,W-6000 FRANKFURT,GERMANY

[2] UNIV PATRAS,DEPT CHEM,PATRAI,GREECE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 22期

关键词：

D O I：

10.1039/c39940002559

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mixture of hexafluoroisopropanol-dichloromethane (1 : 4 v/v) acts as a fast, effective and convenient reagent for cleaving protected peptide fragments with a minimal amount of racemization from 2-chlorotrityl chloride resin.

引用

页码：2559 / 2560

页数：2

共 4 条

[1] ESTERIFICATION OF PARTIALLY PROTECTED PEPTIDE-FRAGMENTS WITH RESINS - UTILIZATION OF 2-CHLOROTRITYLCHLORIDE FOR SYNTHESIS OF LEU-15-GASTRIN-I [J].

BARLOS, K ;

GATOS, D ;

KAPOLOS, S ;

PAPAPHOTIU, G ;

SCHAFER, W ;

YAO, WQ .

TETRAHEDRON LETTERS, 1989, 30 (30) :3947-3950

[2]

BARLOS K, 1991, INT J PEPT PROT RES, V37, P513

[3] SYNTHESIS OF PROTECTED PEPTIDE-FRAGMENTS USING SUBSTITUTED TRIPHENYLMETHYL RESINS [J].

BARLOS, K ;

GATOS, D ;

KALLITSIS, J ;

PAPAPHOTIU, G ;

SOTIRIU, P ;

YAO, WQ ;

SCHAFER, W .

TETRAHEDRON LETTERS, 1989, 30 (30) :3943-3946

[4]

BARLOS K, 1991, ANGEW CHEM, V103, P572

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