TYROSINE KINASE-ACTIVITY AND TRANSFORMATION POTENCY OF BCR-ABL ONCOGENE PRODUCTS

被引：1079
作者：
LUGO, TG
PENDERGAST, AM
MULLER, AJ
WITTE, ON
机构：
[1] UNIV CALIF LOS ANGELES, INST MOLEC BIOL, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF LOS ANGELES, HOWARD HUGHES MED INST, LOS ANGELES, CA 90024 USA
来源：
SCIENCE | 1990年 / 247卷 / 4946期
关键词：
D O I：
10.1126/science.2408149
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of tyrosine kinase activity and quantitative measurement of transformation potency in a single-step assay indicate that variation in bcr exon contribution results in a functional difference between p210bcr-abl and p185bcr-abl proteins. Thus, foreign upstream sequences are important in the deregulation of the kinase activity of the abl product, and the extent of deregulation correlates with the pathological effects of the bcr-abl proteins.
引用
收藏
页码：1079 / 1082
页数：4
相关论文
共 25 条
[1]   THE CHRONIC MYELOGENOUS LEUKEMIA SPECIFIC P210-PROTEIN IS THE PRODUCT OF THE BCR/ABL HYBRID GENE [J].
BEN-NERIAH, Y ;
DALEY, GQ ;
MESMASSON, AM ;
WITTE, ON ;
BALTIMORE, D .
SCIENCE, 1986, 233 (4760) :212-214
[2]  
BRUGGE JS, 1984, J BIOL CHEM, V259, P4550
[3]  
CHEN SJ, 1988, LEUKEMIA, V2, P261
[4]   UNIQUE FORMS OF THE ABL TYROSINE KINASE DISTINGUISH PH1-POSITIVE CML FROM PH1-POSITIVE ALL [J].
CLARK, SS ;
MCLAUGHLIN, J ;
CRIST, WM ;
CHAMPLIN, R ;
WITTE, ON .
SCIENCE, 1987, 235 (4784) :85-88
[5]   EXPRESSION OF A DISTINCTIVE BCR-ABL ONCOGENE IN PH1-POSITIVE ACUTE LYMPHOCYTIC-LEUKEMIA (ALL) [J].
CLARK, SS ;
MCLAUGHLIN, J ;
TIMMONS, M ;
PENDERGAST, AM ;
BEN-NERIAH, Y ;
DOW, LW ;
CRIST, W ;
ROVERA, G ;
SMITH, SD ;
WITTE, ON .
SCIENCE, 1988, 239 (4841) :775-777
[6]   ACTIVATION OF THE C-ABL-ONCOGENE BY VIRAL TRANSDUCTION OR CHROMOSOMAL TRANSLOCATION GENERATES ALTERED C-ABL-PROTEINS WITH SIMILAR INVITRO KINASE PROPERTIES [J].
DAVIS, RL ;
KONOPKA, JB ;
WITTE, ON .
MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (01) :204-213
[7]   A CELLULAR ONCOGENE IS TRANSLOCATED TO THE PHILADELPHIA-CHROMOSOME IN CHRONIC MYELOCYTIC-LEUKEMIA [J].
DEKLEIN, A ;
VANKESSEL, AG ;
GROSVELD, G ;
BARTRAM, CR ;
HAGEMEIJER, A ;
BOOTSMA, D ;
SPURR, NK ;
HEISTERKAMP, N ;
GROFFEN, J ;
STEPHENSON, JR .
NATURE, 1982, 300 (5894) :765-767
[8]   LOCALIZATION OF PREFERENTIAL SITES OF REARRANGEMENT WITHIN THE BCR GENE IN PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA [J].
DENNY, CT ;
SHAH, NP ;
OGDEN, S ;
WILLMAN, C ;
MCCONNELL, T ;
CRIST, W ;
CARROLL, A ;
WITTE, ON .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (11) :4254-4258
[9]   HETEROGENEITY OF CHROMOSOME-22 BREAKPOINT IN PHILADELPHIA-POSITIVE (PH+) ACUTE LYMPHOCYTIC-LEUKEMIA [J].
ERIKSON, J ;
GRIFFIN, CA ;
ARRUSHDI, A ;
VALTIERI, M ;
HOXIE, J ;
FINAN, J ;
EMANUEL, BS ;
ROVERA, G ;
NOWELL, PC ;
CROCE, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (06) :1807-1811
[10]   DELETION OF AN N-TERMINAL REGULATORY DOMAIN OF THE C-ABL TYROSINE KINASE ACTIVATES ITS ONCOGENIC POTENTIAL [J].
FRANZ, WM ;
BERGER, P ;
WANG, JYJ .
EMBO JOURNAL, 1989, 8 (01) :137-147
123