Short-term treadmill exercise preserves sensory-motor function through inhibiting apoptosis in the hippocampus of hypoxic ischemia injury rat pups

被引:20
作者
Choi, Jun-Ho [1 ]
Kim, Tae-Soo [1 ]
Park, Joon-Ki [2 ]
Sim, Young-Je [3 ]
Kim, Kijeong [4 ]
Lee, Sam-Jun [5 ]
机构
[1] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul, South Korea
[2] Incheon Natl Univ, Coll Art & Phys Educ, Div Exercise & Hlth Sci, Incheon, South Korea
[3] Kunsan Natl Univ, Coll Nat Sci, Dept Phys Educ, Gunsan, South Korea
[4] Univ Ulsan, Sch Exercise & Sport Sci, Ulsan, South Korea
[5] Tong Myong Univ, Coll Hlth Social Welf & Educ, Dept Phys Educ, 428 Sinseonno, Busan 608711, South Korea
关键词
Hypoxic ischemia; Hippocampus; Short-term treadmill exercise; Sensory-motor function; Apoptosis;
D O I
10.12965/jer.130055
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Perinatal hypoxic ischemia injury is a common cause of morbidity and mortality in neonates. Physical exercise may ameliorate neurological impairment by impeding neuronal loss following various brain insults. In the present study, the effect of treadmill exercise on sensory-motor function in relation with hippocampal apoptosis following hypoxic ischemia brain injury was investigated. Sensory-motor function was determined by walking initiation test and apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining and caspase-3 immunohistochemistry. On postnatal 7 day, left common carotid artery of the neonatal rats was ligated for two hours and then the neonatal rats were exposed to hypoxia conditions for one hour. The rat pups in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 10 days, starting 22 days after induction of hypoxic ischemia brain injury. Hypoxic ischemia caused sensory-motor disturbance with enhancement of apoptosis in the hippocampus. Short-term treadmill exercise suppressed hypoxic ischemia injury-induced apoptosis in the hippocampus, and preserved sensory-motor function of hypoxic ischemia injury rat pups.
引用
收藏
页码:457 / 462
页数:6
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