INFLUENCE OF VITAMIN-B ON BINDING-PROPERTIES OF SEROTONIN RECEPTORS IN THE CNS OF RATS

被引：39

作者：

DAKSHINAMURTI, K ^{[1
]}

SHARMA, SK ^{[1
]}

BONKE, D ^{[1
]}

机构：

[1] E MERCK AG,DRUG DEV CLIN,DARMSTADT,GERMANY

来源：

KLINISCHE WOCHENSCHRIFT | 1990年 / 68卷 / 02期

关键词：

B Vitamins; CNS; Pyridoxine; Rat; Serotonin receptor binding;

D O I：

10.1007/BF01646863

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment of normal adult rats with pyridoxine or a B-vitamin mixture resembling Neurobion® 1 led to an increase in serotonin content of various brain areas and to a decrease in the number of serotonin S2 receptors. The results indicate that the pyridoxal phosphate level in regions of the brain regulates the extent of decarboxylation of 5-hydroxytryptophan, the precursor of serotonin. The results also suggest a continuum from deficiency in pyridoxine to treatment of animals with a moderate excess of pyridoxine which is reflected in the synthesis and secretion into the synaptic cleft of the neurotransmitter serotonin. © 1990 Springer-Verlag.

引用

页码：142 / 145

页数：4

共 15 条

[1] B-VITAMINS POTENTIATE THE ANTINOCICEPTIVE EFFECT OF DICLOFENAC IN CARRAGEENIN-INDUCED HYPERALGESIA IN THE RAT TAIL PRESSURE TEST [J].