ANTIFUNGAL CYCLIC-PEPTIDES FROM THE TERRESTRIAL BLUE-GREEN-ALGA ANABAENA-LAXA .1. ISOLATION AND BIOLOGICAL PROPERTIES

被引：89

作者：

FRANKMOLLE, WP

LARSEN, LK

CAPLAN, FR

PATTERSON, GML

KNUBEL, G

LEVINE, IA

MOORE, RE

机构：

[1] Department of Chemistry, University of Hawaii, Honolulu

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 09期

关键词：

D O I：

10.7164/antibiotics.45.1451

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Laxaphycins are responsible for the antifungal and cytotoxic activity of crude ethanolic extracts from the cultured blue-green alga Anabaena laxa. These cyclic peptides exhibit an unusual biological synergism when tested for antifungal or cytotoxic effects. The isolation procedure for the peptides, their characterization and biological activities are described here along with experiments demonstrating synergism between the two major laxaphycins.

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页码：1451 / 1457

页数：7

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