CEREBROSPINAL-FLUID ANTIBODIES TO CORONAVIRUS IN PATIENTS WITH PARKINSONS-DISEASE

被引：140

作者：

FAZZINI, E

FLEMING, J

FAHN, S

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR,COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

[2] UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024

来源：

MOVEMENT DISORDERS | 1992年 / 7卷 / 02期

关键词：

PARKINSONS DISEASE; CORONAVIRUS; ENVIRONMENTAL FACTORS;

D O I：

10.1002/mds.870070210

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The etiology of Parkinson's disease remains unknown, and a search for environmental agents continues. In 1985, Fishman (10) induced infection of the basal ganglia by a coronavirus in mice. Although coronavirus is recognized primarily as a respiratory pathogen in humans, its affinity for the basal ganglia led us to investigate its possible role in human Parkinson's disease. The cerebrospinal fluid of normal controls (CTL) (n = 18), and patients with Parkinson's disease (PD (n = 20) and other neurological disease (OND) (n = 29) was analyzed in a blinded manner by enzyme-linked immunosorbent assay [measurements in optical density (OD) units] for antibody response to four coronavirus antigens: mouse hepatitis virus JHM (J) and A59 (A), and human coronavirus 229E (E) and OC43 (O). When compared with CTL, PD patients had an elevated (p < 0.05) mean OD response to J (0.0856 vs. 0.0207) and A (0.1722 vs. 0.0636). Response (p > 0.05) to O (0.0839 vs. 0.0071) was greater than that to E (0.1261 vs. 0.0743). When compared to OND, PD patients had an elevated mean OD response to J (0.0856 vs. 0.0267, p < 0.05). Responses (p > 0.05) to A (0.1722 vs. 0.0929) and O (0.0839 vs. 0.0446) were greater than that to E (0.1261 vs. 0.0946). These results suggest that there may be an association between coronavirus and PD.

引用

页码：153 / 158

页数：6

共 27 条

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