ADRIAMYCIN RESISTANCE AND RADIATION RESPONSE

被引：26

作者：

BELLI, JA

HARRIS, JR

机构：

[1] Department of Radiation Therapy, Joint Center for Radiation Therapy, Harvard Medical School, Boston

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1979年 / 5卷 / 08期

关键词：

Adriamycin; Drug resistance; Mutation; Radiation response;

D O I：

10.1016/0360-3016(79)90644-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mammalian cells (V79) in culture developed resistance to Adriamycin during continuous exposure to low levels of drug. This resistance was accompanied by change in X-ray survival properties which, in turn depended upon the isolation of subpopulations from resistant sub lines. These changes in X-ray survival properties were characterized by reduced DQ values and a decrease in the D0. However, these changes were not observed together in the same cell sub line. Adriamycin-resistant cells did not appear to be radiation damage repair deficient. Other phenotypic changes (cell morphology, DNA content and chromosome number) suggested mutational events coincident with the development of Adriamycin resistance. © 1979.

引用

页码：1231 / 1234

页数：4

共 6 条

[1]

BELLI JA, 1977, CANCER RES, V37, P1624

[2]

BELLI JA, 1978, FRONT RAD THER ONCOL, V13, P9

[3] ADRIAMYCIN - NEW ANTICANCER DRUG WITH SIGNIFICANT CLINICAL ACTIVITY [J].