STRUCTURAL ORGANIZATION OF FREE AND ESTERIFIED CHOLESTEROL IN HUMAN HIGH-DENSITY LIPOPROTEINS - 100.6 MHZ C-13-NMR STUDY

被引：12
作者：
HAUSER, H [1 ]
KOSTNER, GM [1 ]
机构：
[1] UNIV GRAZ,INST MED BIOCHEM,A-8010 GRAZ,AUSTRIA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 573卷 / 02期
关键词：
!sup]13[!/sup]C NMR; Cholesterol distribution; HDL;
D O I：
10.1016/0005-2760(79)90070-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structural organization of free and esterified cholesterol in human high density lipoproteins has been studied by high-field 1H and 13C NMR. The measurements are consistent with free cholesterol being present in at least two different environments. Part of the free cholesterol is oriented in the outer surface layer of the high density lipoprotein particle in contact with phospholipid or apoprotein, or both. The rest is probably present in the liquid, hydrophobic core of the HDL particle. © 1979.
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页码：375 / 381
页数：7
相关论文
共 24 条
[11]  
HAUSER H, 1978, LIFE SCI, V15, P115
[12]   INCORPORATION OF EXCESS CHOLESTEROL BY HIGH-DENSITY SERUM-LIPOPROTEINS [J].
JONAS, A ;
HESTERBERG, LK ;
DRENGLER, SM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 528 (01) :47-57
[13]   STUDIES OF COMPOSITION AND STRUCTURE OF PLASMA LIPOPROTEINS - SEPARATION AND QUANTIFICATION OF LIPOPROTEIN FAMILIES OCCURRING IN HIGH-DENSITY LIPOPROTEINS OF HUMAN PLASMA [J].
KOSTNER, G ;
ALAUPOVI.P .
BIOCHEMISTRY, 1972, 11 (18) :3419-&
[14]   SEPARATION OF HUMAN-SERUM HIGH-DENSITY LIPOPROTEINS BY HYDROXYAPATITE COLUMN CHROMATOGRAPHY - EVIDENCE FOR PRESENCE OF DISCRETE SUBFRACTIONS [J].
KOSTNER, GM ;
HOLASEK, A .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 488 (03) :417-431
[15]   STUDIES ON STRUCTURE OF LIPOPROTEIN A OF HUMAN HIGH-DENSITY LIPOPROTEIN HDL3 - SPHERICALLY AVERAGED ELECTRON-DENSITY DISTRIBUTION [J].
LAGGNER, P ;
MULLER, K ;
KRATKY, O ;
KOSTNER, G ;
HOLASEK, A .
FEBS LETTERS, 1973, 33 (01) :77-80
[16]  
MILLER GJ, 1975, LANCET, V1, P16
[17]   LIPID-PROTEIN INTERACTIONS IN PLASMA LIPOPROTEINS [J].
MORRISETT, JD ;
JACKSON, RL ;
GOTTO, AM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 472 (02) :93-133
[18]  
MULLEN K, 1976, FOURIER TRANSFORM NM, P33
[19]   X-RAY SMALL-ANGLE SCATTERING OF HUMAN PLASMA HIGH-DENSITY LIPOPROTEIN LPA FROM HDL2 - APPLICATION OF A NEW EVALUATION METHOD [J].
MULLER, K ;
LAGGNER, P ;
KRATKY, O ;
KOSTNER, G ;
HOLASEK, A ;
GLATTER, O .
FEBS LETTERS, 1974, 40 (01) :213-218
[20]   TEMPERATURE-DEPENDENT C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF HUMAN-SERUM LOW-DENSITY LIPOPROTEINS [J].
SEARS, B ;
DECKELBAUM, RJ ;
JANIAK, MJ ;
SHIPLEY, GG ;
SMALL, DM .
BIOCHEMISTRY, 1976, 15 (19) :4151-4157
123