A Family Predisposition to Adult T-Cell Leukemia

被引：4

作者：

Nomura, Kouichiro ^{[1
]}

Utsunomiya, Atae ^{[2
]}

Furushou, Hironori ^{[2
]}

Tara, Mitsutoshi ^{[3
]}

Hazeki, Masashi ^{[4
]}

Tokunaga, Masayoshi ^{[5
]}

Uozumi, Kimiharu ^{[6
]}

Hanada, Shuichi ^{[6
]}

Yashiki, Shinji ^{[7
]}

Tajima, Kazuo ^{[8
]}

Sonoda, Shunro ^{[7
]}

机构：

[1] Kagoshima Prefectural Hokusatsu Hosp, Internal Med, Kagoshima, Japan

[2] Imamura Bun Hosp, Dept Hematol, Kamoikeshinmachi 11-23, Kagoshima 8900064, Japan

[3] Kagoshima Municipal Hosp, Kagoshima, Japan

[4] Hazeki Hosp, Istanbul, Turkey

[5] Kodama Hosp, Oita, Japan

[6] Kagoshima Univ, Fac Med, Dept Internal Med 2, Kagoshima, Japan

[7] Kagoshima Univ, Fac Med, Dept Virol, Kagoshima, Japan

[8] Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2006年 / 46卷 / 02期

关键词：

adult T-cell leukemia; familial ATL; HTLV-1; HLA allele;

D O I：

10.3960/jslrt.46.67

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report here the rare case of a family predisposed to adult T-cell leukemia (ATL). Six of seven siblings developed ATL with ages of onset of 77, 48, 60, 64, 72, and 62 years old. Although virological tests for human T-lymphotropic virus type 1 were unavailable for two of the six patients, all were diagnosed with ATL based on their clinical, hematological, and histopathological features. Two of the six patients were tested for HLA haplotypes using fresh blood samples, and both were carriers of the HLA-A* 26 allele known in the southern Japanese population to be susceptible to ATL. This series of genetic traits may help explain the familial predisposition to ATL.

引用

页码：67 / 71

页数：5

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