POLYAMIDE METHOD OF SOLID-PHASE PEPTIDE AND OLIGONUCLEOTIDE SYNTHESIS

被引：142

作者：

ATHERTON, E

GAIT, MJ

SHEPPARD, RC

WILLIAMS, BJ

机构：

[1] MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH England, Hills Road

来源：

BIOORGANIC CHEMISTRY | 1979年 / 8卷 / 03期

关键词：

D O I：

10.1016/0045-2068(79)90062-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A versatile system of solid-phase peptide synthesis based on polar polyamide resins, a range of reversible peptide-resin linkage agents, and Nα-t-butoxycarbonyl or fluorenylmethoxycarbonyl-amino acids has been developed. Principles used in the design of the method are discussed and illustrated by synthesis of a number of natural peptides. Application of these principles to oligodeoxyribonucleotide synthesis has provided for the first time a practical solid phase method in the nucleotide field. © 1979.

引用

页码：351 / 370

页数：20

共 51 条

[1] STUDIES ON POLYNUCLEOTIDES .102. USE OF AROMATIC ISOCYANATES FOR SELECTIVE BLOCKING OF TERMINAL 3'-HYDROXYL GROUP IN PROTECTED DEOXYRIBOOLIGONUCLEOTIDES [J].