RNA-triggered gene silencing

被引：517

作者：

Fire, A ^{[1
]}

机构：

[1] Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 09期

关键词：

D O I：

10.1016/S0168-9525(99)01818-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Double-stranded RNA (dsRNA) has recently been shown to trigger sequence-specific gene silencing in a wide variety of organisms, including nematodes, plants, trypanosomes, fruit flies and planaria; meanwhile an as yet uncharacterized RNA trigger has been shown to induce DNA methylation in several different plant systems. In addition to providing a surprisingly effective set of tools to interfere selectively with gene function, these observations are spurring new inquiries to understand RNA-triggered genetic-control mechanisms and their biological roles.

引用

页码：358 / 363

页数：6

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