DOPAMINE D-1 RECEPTOR AGONIST-INDUCED GROOMING IS BLOCKED BY THE OPIOID RECEPTOR ANTAGONIST NALOXONE

被引：8
作者：
STOESSL, AJ
机构：
[1] UNIV WESTERN ONTARIO, DEPT CLIN NEUROL SCI, LONDON, ON, CANADA
[2] ROBARTS RES INST, LONDON N6A 5C1, ON, CANADA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 03期
基金：
英国医学研究理事会;
关键词：
DOPAMINE; GROOMING; OPIOID; VACUOUS CHEWING MOVEMENT;
D O I：
10.1016/0014-2999(94)90657-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of the opioid receptor antagonist naloxone on behavioural responses to the dopamine D1( )receptor agonist SKF 38393 ((+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3- hydrochloride) were assessed in the rat. SKF 38393 (5 mg/kg s.c.) induced grooming and vacuous chewing mouth movements. SKF 38393-induced grooming was dose-dependently attenuated by naloxone (0.375-1.5 mg/kg s.c.), while vacuous chewing movements were unaffected. These findings suggest that dopamine D-1 receptor agonist-induced grooming is dependent upon opioid systems, while vacuous chewing movements are likely to be mediated via different pathways.
引用
收藏
页码：301 / 303
页数：3
相关论文
共 15 条
[1]  
CRISWELL HE, 1992, NEUROPSYCHOPHARMACOL, V7, P95
[2]  
Deakin M., 1993, Society for Neuroscience Abstracts, V19, P406
[3]   TOPOGRAPHY OF DOPAMINE BEHAVIORS MEDIATED BY D1-RECEPTOR AND D2-RECEPTOR REVEALED BY INTRASTRIATAL INJECTION OF SKF-38393, LISURIDE AND APOMORPHINE IN RATS WITH A UNILATERAL 6-HYDROXYDOPAMINE-INDUCED LESION [J].
FLETCHER, GH ;
STARR, MS .
NEUROSCIENCE, 1987, 20 (02) :589-597
[4]  
GREIDANUS TBV, 1989, EUR J PHARMACOL, V173, P227
[5]   SELECTIVE LOCALIZATION OF STRIATAL D1 RECEPTORS TO STRIATONIGRAL NEURONS [J].
HARRISON, MB ;
WILEY, RG ;
WOOTEN, GF .
BRAIN RESEARCH, 1990, 528 (02) :317-322
[6]   OPIOID RECEPTORS AND INHIBITION OF DOPAMINE-SENSITIVE ADENYLATE-CYCLASE IN SLICES OF RAT-BRAIN REGIONS RECEIVING A DENSE DOPAMINERGIC INPUT [J].
HEIJNA, MH ;
BAKKER, JM ;
HOGENBOOM, F ;
MULDER, AH ;
SCHOFFELMEER, ANM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 229 (2-3) :197-202
[7]   CHRONIC TREATMENT WITH HALOPERIDOL ACCELERATES BIOSYNTHESIS OF ENKEPHALINS IN RAT STRIATUM [J].
HONG, JS ;
YANG, HYT ;
GILLIN, JC ;
DIGIULIO, AM ;
FRATTA, W ;
COSTA, E .
BRAIN RESEARCH, 1979, 160 (01) :192-195
[8]   EFFECTS OF INTRASTRIATAL INJECTIONS OF SELECTIVE DOPAMINE D-1 AND D-2-AGONISTS AND ANTAGONISTS ON JAW MOVEMENTS OF RATS [J].
KOSHIKAWA, N ;
AOKI, S ;
HIRUTA, M ;
TOMIYAMA, K ;
KOBAYASHI, M ;
TSUBOI, Y ;
IWATA, K ;
SUMINO, R ;
STEPHENSON, JD .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 163 (2-3) :227-236
[9]   COMPARATIVE NEUROANATOMICAL DISTRIBUTION OF THE KAPPA-OPIOID AND MU-OPIOID RECEPTORS IN GUINEA-PIG BRAIN SECTIONS [J].
LAHTI, RA ;
MICKELSON, MM ;
JODELIS, KS ;
MCCALL, JM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 166 (03) :563-566
[10]   FETAL BEHAVIOR AND THE ENDOGENOUS OPIOID SYSTEM - D1-DOPAMINE RECEPTOR INTERACTIONS WITH THE KAPPA OPIOID SYSTEM [J].
SMOTHERMAN, WP ;
MOODY, CA ;
SPEAR, LP ;
ROBINSON, SR .
PHYSIOLOGY & BEHAVIOR, 1993, 53 (01) :191-197
12