OLFACTORY BULBECTOMY AS A MODEL FOR AGITATED HYPOSEROTONERGIC DEPRESSION

被引：156

作者：

LUMIA, AR ^{[1
]}

TEICHER, MH ^{[1
]}

SALCHLI, F ^{[1
]}

AYERS, E ^{[1
]}

POSSIDENTE, B ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED,MCCLEAN HOSP,MAILMAN LABS PSYCHIAT RES, DEPT PSYCHIAT, BOSTON, MA 02115 USA

来源：

BRAIN RESEARCH | 1992年 / 587卷 / 02期

关键词：

OLFACTORY BULB; SEROTONIN; AMITRIPTYLINE; WHEEL-RUNNING RHYTHM; SEXUAL BEHAVIOR; RAT; MONOAMINE;

D O I：

10.1016/0006-8993(92)90995-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ablation of olfactory bulbs in rats reduced male sexual behavior, and altered the distribution of wheel-running activity between the light and dark phases of a 12:12 LD photoperiod. These effects were partially reversed by the tricyclic antidepressant amitriptyline. Olfactory bulbectomy also altered serotonin metabolism (5-HIAA/5-HT ratio) in the frontal cortex, nucleus accumbens, hippocampus and corpus striatum. These observations support the hypothesis that olfactory bulbectomy in rodents serves as a model of agitated hyposerotonergic depression.

引用

页码：181 / 185

页数：5

共 29 条

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