Spatial Structure of Heptapeptide A beta(16-22) in a Solution and in the Complex between the Heptapeptide and a Model Biological Membrane

被引：0

作者：

Usachev, K. S. ^{[1
]}

Yulmetov, A. R. ^{[2
,3
]}

Filippov, A., V ^{[4
,5
]}

Antsutkin, O. N. ^{[6
,7
]}

Afonin, S. ^{[8
,9
]}

Aganov, A., V ^{[10
,11
,12
]}

Klochkov, V. V. ^{[10
,11
]}

机构：

[1] Kazan Privolzhsky Fed Univ, Dept Gen Phys, Kazan, Russia

[2] Kazan Privolzhsky Fed Univ, Phys & Math Sci, Kazan, Russia

[3] Kazan Privolzhsky Fed Univ, Chair Gen Phys, Kazan, Russia

[4] Kazan Privolzhsky Fed Univ, Phys & Math, Kazan, Russia

[5] Kazan Privolzhsky Fed Univ, Dept Phys Mol Syst, Kazan, Russia

[6] Univ Lulea, Chem, S-97187 Lulea, Sweden

[7] Univ Lulea, Dept Appl Chem & Geol, S-97187 Lulea, Sweden

[8] Karlsruhe Inst Technol, Chem, D-76021 Karlsruhe, Germany

[9] Karlsruhe Inst Technol, D-76021 Karlsruhe, Germany

[10] Kazan Volga Fed Univ, Chem Sci, Kazan, Russia

[11] Kazan Volga Fed Univ, Dept Gen Phys, Kazan, Russia

[12] Kazan Volga Fed Univ, Inst Phys, Kazan, Russia

来源：

UCHENYE ZAPISKI KAZANSKOGO UNIVERSITETA-SERIYA ESTESTVENNYE NAUKI | 2011年 / 153卷 / 03期

关键词：

structure; beta-amyloid; micelles; NMR H-1 spectroscopy; two-dimensional NMR (TOCSY; HSQC-HECADE; NOESY); spectroscopy;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The spatial structure of an active fragment of beta-amyloid A beta(1-40) heptapeptide A beta(6-22) (Lys-Leu-Val-Phe-Phe-Ala-Glu) in a solution and the spatial structure of the complex between the heptapeptide and a model cell membrane surface (a micelle based on sodium dodecyl sulfate) were investigated and described by H-1 NMR spectroscopy and two-dimensional NMR (TOCSY, HSQC-HECADE, NOESY) spectroscopy. The complexation was confirmed by the change in the chemical shifts in the heptapeptide's H-1 NMR spectra as well as by the signs and values of the nuclear Overhauser effect (NOE) in various media. A comparison of the heptapeptide's spatial structure in a borate buffer solution and its structure in the complex between Lys-Leu-Val-Phe-Phe-Ala-Glu and the model cell membrane surface was made.

引用

页码：91 / 106

页数：3

共 10 条

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Filippov, Andrey V.
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Afonin, Sergii
Klochkov, Vladimir V.
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