THE ROLE OF REDUCTIVE AND OXIDATIVE-METABOLISM IN THE TOXICITY OF MITOXANTRONE, ADRIAMYCIN AND MENADIONE IN HUMAN-LIVER DERIVED HEP-G2 HEPATOMA-CELLS

被引：51
作者：
DUTHIE, SJ [1 ]
GRANT, MH [1 ]
机构：
[1] UNIV ABERDEEN,DEPT MED & THERAPEUT,CLIN PHARMACOL UNIT,ABERDEEN AB9 2ZD,SCOTLAND
来源：
BRITISH JOURNAL OF CANCER | 1989年 / 60卷 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/bjc.1989.314
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：566 / 571
页数：6
相关论文
共 36 条
  • [1] ANUFORO DC, 1978, IN VITRO CELL DEV B, V14, P981
  • [2] ANTITUMOR ANTHRACYCLINES - RECENT DEVELOPMENTS
    ARCAMONE, F
    [J]. MEDICINAL RESEARCH REVIEWS, 1984, 4 (02) : 153 - 188
  • [3] PROTECTIVE ROLE OF THE GLUTATHIONE REDOX CYCLE AGAINST ADRIAMYCIN-MEDIATED TOXICITY IN ISOLATED HEPATOCYTES
    BABSON, JR
    ABELL, NS
    REED, DJ
    [J]. BIOCHEMICAL PHARMACOLOGY, 1981, 30 (16) : 2299 - 2304
  • [4] BASRA J, 1985, ANTI-CANCER DRUG DES, V1, P45
  • [5] BUTLER J, 1987, British Journal of Cancer, V55, P53
  • [6] MUTAGENICITY OF QUINONES - PATHWAYS OF METABOLIC-ACTIVATION AND DETOXIFICATION
    CHESIS, PL
    LEVIN, DE
    SMITH, MT
    ERNSTER, L
    AMES, BN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (06): : 1696 - 1700
  • [7] MITOXANTRONE FOR THE TREATMENT OF ADVANCED BREAST-CANCER - SINGLE-AGENT THERAPY IN PREVIOUSLY UNTREATED PATIENTS
    CORNBLEET, MA
    STUARTHARRIS, RC
    SMITH, IE
    COLEMAN, RE
    RUBENS, RD
    MCDONALD, M
    MOURIDSEN, HT
    RAINER, H
    VANOOSTEROM, AT
    SMYTH, JF
    [J]. EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1984, 20 (09): : 1141 - 1146
  • [8] MITOXANTRONE AFFECTS TOPOISOMERASE ACTIVITIES IN HUMAN-BREAST CANCER-CELLS
    CRESPI, MD
    IVANIER, SE
    GENOVESE, J
    BALDI, A
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 136 (02) : 521 - 528
  • [9] MENADIONE-INDUCED CYTO-TOXICITY IS ASSOCIATED WITH PROTEIN THIOL OXIDATION AND ALTERATION IN INTRACELLULAR CA-2+ HOMEOSTASIS
    DIMONTE, D
    BELLOMO, G
    THOR, H
    NICOTERA, P
    ORRENIUS, S
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1984, 235 (02) : 343 - 350
  • [10] DOROSHOW JH, 1983, BIOCHEM PHARMACOL, V32, P293
1234