EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON BEHAVIOUR OF MICE IN THE "OPEN FIELD"

Mild traumatic brain injury, often identified with brain concussion, is about 80% of all cases of traumatic brain injury. Due to insufficient sensitivity of standard diagnostic methods pathophysiology of mild traumatic brain injury remains poorly understood. Until recently, there was information only about external manifestations of concussion, such as loss of consciousness, amnesia, sleep disorders, emotional instability, etc. The aim of our research was to study changes in behavior of mice after experimental repetitive mild traumatic brain injury. In the "Open field", we tested mice andobserved a decrease of locomotor activity and increase of anxiety level at days 5 and 10 since the first impact and recovery of respective characteristics to the level of control at day 30.