IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN IN HUMAN PROSTATIC-CANCER

被引：58

作者：

HENKE, RP ^{[1
]}

KRUGER, E ^{[1
]}

AYHAN, N ^{[1
]}

HUBNER, D ^{[1
]}

HAMMERER, P ^{[1
]}

HULAND, H ^{[1
]}

机构：

[1] UNIV HAMBURG,DEPT UROL,D-20246 HAMBURG,GERMANY

来源：

JOURNAL OF UROLOGY | 1994年 / 152卷 / 04期

关键词：

PROSTATIC NEOPLASMS; PROGNOSIS; PROTEIN P53;

D O I：

10.1016/S0022-5347(17)32571-5

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue sections from 73 radical-prostatectomy specimens were studied immunohistochemically for the presence of p53 protein. In seven specimens numerous tumor cells showed a strong nuclear immunostaining. An additional 27 revealed a more discrete and focal accumulation of p53 protein. Comparison of the pathologic characteristics of the p53-negative and -positive groups showed that the presence of p53 protein closely correlated with more advanced tumor stages (p <0.00001), with higher primary (p 0.0004), combined (p <0.0001) and worst (p <0.0001) Gleason grades, and with larger total (p = 0.0001) and high-grade (p <0.0001) tumor volumes. No staining was found in areas of benign hyperplasia or in well-differentiated tumor zones. Our results suggest that the accumulation of p53 protein to immunohistochemically detectable concentrations is not a feature of low-grade cancer. This finding implies that abnormal p53 accumulation might be involved in the process of prostatic cancer progression.

引用

页码：1297 / 1301

页数：5

共 42 条

[1]

BOOKSTEIN R, 1993, CANCER RES, V53, P3369

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