INHIBITION OF HEPATOCYTE GAP JUNCTIONAL COMMUNICATION BY 25-HYDROXYCHOLESTEROL MAY BE MEDIATED THROUGH FREE-RADICALS

被引：0
|
作者：
GUO, XB [1 ]
OHNO, YS [1 ]
TAKANAKA, A [1 ]
机构：
[1] NATL INST HYG SCI,DIV PHARMACOL,SETAGAYA KU,TOKYO 158,JAPAN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1993年 / 248卷 / 04期
关键词：
25-HYDROXYCHOLESTEROL; GAP JUNCTION; HEPATOCYTES; FREE RADICAL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
25-Hydroxycholesterol, an autoxidation product of cholesterol, has been shown to inhibit gap junctional communication between rat hepatocytes. In this study, we investigated whether free radicals are responsible for the effect of 25-hydroxycholesterol on hepatocytes. Addition of superoxide dismutase, hydroxyl radical scavenger mannitol, or the antioxidants diphenylphenylenediamine and cr-tocopherol markedly decreased the inhibitory effect of 25-hydroxycholesterol. However, addition of catalase or the catalase inhibitor aminotriazole did not influence the inhibition of gap junctional communication by 25-hydroxycholesterol. Data from this study suggest that free radicals other than hydrogen peroxide are involved in the mechanism of 25-hydroxycholesterol-induced inhibition of gap junctional communication.
引用
收藏
页码：337 / 340
页数：4
相关论文
共 28 条
  • [1] TPA-INDUCED INHIBITION OF GAP JUNCTIONAL INTERCELLULAR COMMUNICATION IS NOT MEDIATED THROUGH FREE-RADICALS
    HASLER, CM
    FRICK, MA
    BENNINK, MR
    TROSKO, JE
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 103 (03) : 389 - 398
  • [2] INHIBITION OF MOUSE HEPATOCYTE INTERCELLULAR COMMUNICATION BY PARAQUAT-GENERATED OXYGEN FREE-RADICALS
    RUCH, RJ
    KLAUNIG, JE
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1988, 94 (03) : 427 - 436
  • [3] Macrophage inhibition of lymphocyte and tumor cell growth is mediated by 25-hydroxycholesterol in the cell membrane
    Kato, H
    Horino, A
    Tancichi, M
    Komuro, K
    Uchida, T
    JOURNAL OF LEUKOCYTE BIOLOGY, 1999, : 20 - 20
  • [4] Macrophage inhibition of lymphocyte and tumor cell growth is mediated by 25-hydroxycholesterol in the cell membrane
    Kato, H
    Horino, A
    Taneichi, M
    Fukuchi, N
    Eto, Y
    Ushijima, H
    Komuro, K
    Uchida, T
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1998, 117 (01) : 78 - 84
  • [5] INHIBITION OF HEPATOCYTE GAP JUNCTIONAL INTERCELLULAR COMMUNICATION BY ENDOSULFAN, CHLORDANE AND HEPTACHLOR
    RUCH, RJ
    FRANSSON, R
    FLODSTROM, S
    WARNGARD, L
    KLAUNIG, JE
    CARCINOGENESIS, 1990, 11 (07) : 1097 - 1101
  • [6] 25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation
    Shrivastava-Ranjan, Punya
    Bergeron, Eric
    Chakrabarti, Ayan K.
    Albarino, Cesar G.
    Flint, Mike
    Nichol, Stuart T.
    Spiropoulou, Christina F.
    MBIO, 2016, 7 (06):
  • [7] THE EFFECTS OF MANGANESE ON THE CHOLINERGIC RECEPTOR INVIVO AND INVITRO MAY BE MEDIATED THROUGH MODULATION OF FREE-RADICALS
    DONALDSON, J
    LABELLA, FS
    NEUROTOXICOLOGY, 1984, 5 (01) : 105 - 112
  • [8] 25-Hydroxycholesterol protecting from cerebral ischemia-reperfusion injury through the inhibition of STING activity
    Lin, Feihong
    Yao, Xinyu
    Kong, Chang
    Liu, Xia
    Zhao, Zhangfan
    Rao, Suhuan
    Wang, Lu
    Li, Shan
    Wang, Junlu
    Dai, Qinxue
    AGING-US, 2021, 13 (16): : 20149 - 20163
  • [9] 25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway
    Ichikawa, Tomohiro
    Sugiura, Hisatoshi
    Koarai, Akira
    Kikuchi, Takashi
    Hiramatsu, Masataka
    Kawabata, Hiroki
    Akamatsu, Keiichiro
    Hirano, Tsunahiko
    Nakanishi, Masanori
    Matsunaga, Kazuto
    Minakata, Yoshiaki
    Ichinose, Masakazu
    EXPERIMENTAL CELL RESEARCH, 2013, 319 (08) : 1176 - 1186
  • [10] Inhibition of mouse hepatocyte gap junctional intercellular communication by phenobarbital correlates with strain-specific hepatocarcinogenesis
    Warner, KA
    Fernstrom, MJ
    Ruch, RJ
    TOXICOLOGICAL SCIENCES, 2003, 71 (02) : 190 - 197
123