TAU-PROTEIN AND PAIRED HELICAL FILAMENTS OF ALZHEIMERS-DISEASE

被引：30
作者：
CROWTHER, RA [1 ]
机构：
[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 02期
关键词：
D O I：
10.1016/S0959-440X(05)80153-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Significant advances have recently been made in understanding the nature of the Alzheimer paired helical filament. This appears to consist entirely of abnormally phosphorylated microtubule-associated protein Tau. Filaments resembling those found in Alzheimer's disease have been assembled in vitro from fragments of Tau protein spanning the microtubule-binding repeat region.
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页码：202 / 206
页数：5
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