TAU-PROTEIN AND PAIRED HELICAL FILAMENTS OF ALZHEIMERS-DISEASE

被引：30

作者：

CROWTHER, RA ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(05)80153-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant advances have recently been made in understanding the nature of the Alzheimer paired helical filament. This appears to consist entirely of abnormally phosphorylated microtubule-associated protein Tau. Filaments resembling those found in Alzheimer's disease have been assembled in vitro from fragments of Tau protein spanning the microtubule-binding repeat region.

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页码：202 / 206

页数：5

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