HETEROCYCLIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE - 3-HYDROXYPYRIDAZOPYRIMIDINE, 3-HYDROXYPYRIDOPYRIMIDINE AND 3-HYDROXYQUINAZOLINE-2,4(1H,3H)DIONE DERIVATIVES

被引：4

作者：

GROUTAS, WC

CASTRISOS, JC

STANGA, MA

KUANG, RZ

VENKATARAMAN, R

EPP, JB

BRUBAKER, MJ

CHONG, LS

机构：

[1] Department of Chemistry, Wichita State University, Wichita

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80307-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several heterocyclic compounds derived from 3-hydroxypyridazopyrimidine-(I), 3-hydroxypyridopyrimidine-(II) and 3-hydroxyquinazoline-2,4(1H,3H)diones-(III) have been found to be time-dependent irreversible inhibitors of human leukocyte elastase.

引用

页码：1163 / 1168

页数：6

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