Leptin and its metabolic impact on lipodystrophy

被引：0
|
作者：
Lau, Eva [1 ,2 ]
Freitas, Paula [1 ,2 ]
Oliveira, Ana Isabel [1 ,2 ]
Carvalho, Davide [1 ,2 ]
机构：
[1] Ctr Hosp Sao Joao, Dept Endocrinol Diabet & Metab, EPE, Oporto, Portugal
[2] Univ Porto, Fac Med, Oporto, Portugal
来源：
REVISTA PORTUGUESA DE ENDOCRINOLOGIA DIABETES E METABOLISMO | 2014年 / 9卷 / 01期
关键词：
Leptin; Lipodystrophy; Obesity; Metabolic;
D O I：
10.1016/j.rpedm.2014.03.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Leptin is a hormone produced predominantly by adipocytes, essential in energy homeostasis regulation. It acts as a sensor of body fat mass stores, being involved in lipids control in non adipose tissues, food intake and thermogenesis with subsequent metabolic implications. Leptin administration in replacement doses constitutes an important step forward in the understanding and treatment of various lipodystrophic syndromes, conditions characterized by a hypoleptinemic state. Particularly, recombinant methionyl leptin administration in patients with lipodystrophy exhibiting severe hypoleptinemia ameliorated hyperinsulinemia, insulin resistance, hyperglycemia, hypertriglyceridemia, and neuroendocrine abnormalities without significant adverse effects, providing the rationale for metreleptin treatment in these patients. (C) 2013 Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo. Published by Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：36 / 40
页数：5
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