SYNTHESIS AND MASS-SPECTROMETRY OF DEUTERATED METHADONE AND METHADONE METABOLITES

被引：7

作者：

KANG, GI ^{[1
]}

ABBOTT, FS ^{[1
]}

BURTON, R ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,VANCOUVER V6T 1W5,BC,CANADA

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 05期

关键词：

D O I：

10.1002/bms.1200060502

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Deuterated methadone, 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenyl pyrrolidine, 2‐ethyl‐5‐methyl‐3,3‐diphenyl‐1‐pyrroline, 1,5‐dimethyl‐3,3‐diphenyl‐2‐pyrrolidone and 4‐dimethylamino‐2,2‐diphenylpentanoic acid have been synthesized for application to metabolic studies of methadone and as potential internal standards for selected ion monitoring methods. Mass fragmentation patterns are described based upon comparisons between labeled and unlabeled derivatives. Copyright © 1979 Heyden & Son Ltd

引用

页码：179 / 186

页数：8

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