NEW CYCLOSPORINE-A ANALOG - SYNTHESIS AND IMMUNOSUPPRESSIVE ACTIVITY

被引：3

作者：

ROZYCKI, J ^{[1
]}

ROLKA, K ^{[1
]}

WIECZOREK, Z ^{[1
]}

ZIMECKI, M ^{[1
]}

KUPRYSZEWSKI, G ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST IMMUNOL & EXPTL THERAPY,PL-53114 WROCLAW,POLAND

来源：

MOLECULAR IMMUNOLOGY | 1992年 / 29卷 / 09期

关键词：

D O I：

10.1016/0161-5890(92)90035-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A synthetic analogue of cyclosporine A, in which an unusual amino acid (4R)-N-methyl-4-butenyl-4-methyl-L-threonine (MeBmt) is replaced with L-threonine (Thr), was synthesized by the solid phase method. Its activity in the humoral response to sheep red blood cells in vitro and in vivo in mice was practically the same as that of cyclosporine A used as a standard, whereas the analogue studied exerted a significantly stronger effect in the delayed type hypersensitivity to sheep red blood cells in mice.

引用

页码：1043 / 1047

页数：5

共 15 条

[1] BOREL JF, 1986, PROG ALLERGY, V38
[2] N-METHYLAMINO ACIDS IN PEPTIDE-SYNTHESIS .5. SYNTHESIS OF N-TERT-BUTYLOXYCARBONYL, N-METHYLAMINO ACIDS BY N-METHYLATION
CHEUNG, ST
BENOITON, NL
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (05): : 906 - 910
[3] CHRISTENSEN T, 1979, PEPTIDES STRUCTURE B, P385
[4] CYCLOSPORIN-A AND C NEW METABOLITES FROM TRICHODERMA-POLYSPORUM (LINK EX PERS) RIFAI
DREYFUSS, M
HARRI, E
HOFMANN, H
KOBEL, H
PACHE, W
TSCHERTER, H
[J]. EUROPEAN JOURNAL OF APPLIED MICROBIOLOGY, 1976, 3 (02): : 125 - 133
[5] HORIKI K, 1978, CHEM LETT, V1, P165
[6] COLOR TEST FOR DETECTION OF FREE TERMINAL AMINO GROUPS IN SOLID-PHASE SYNTHESIS OF PEPTIDES
KAISER, E
COLESCOT.RL
BOSSINGE.CD
COOK, PI
[J]. ANALYTICAL BIOCHEMISTRY, 1970, 34 (02) : 595 - &
[7] LAGRANGE PH, 1975, J IMMUNOL, V114, P447
[8] IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE
MISHELL, RI
DUTTON, RW
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1967, 126 (03) : 423 - &
[9] DI-TERT-BUTYL-DICARBONATE, A USEFUL TERT-BUTYLOXYCARBONYLATING REAGENT
MORODER, L
HALLETT, A
WUNSCH, E
KELLER, O
WERSIN, G
[J]. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1976, 357 (11): : 1651 - 1653
[10] SYNTHESIS AND ANTIMITOGENIC ACTIVITIES OF 4 ANALOGS OF CYCLOSPORINE-A MODIFIED IN THE 1-POSITION
RICH, DH
DHAON, MK
DUNLAP, B
MILLER, SPF
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (06) : 978 - 984

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