SYNTHESIS OF SOME O-ALKYL O-(2-METHOXYCARBONYLPHENYL) N-SUBSTITUTED PHOSPHORAMIDATES AS FUNGICIDES

The organophosphorus toxicants act by inhibition of esterases by phosphorylation mechanism of active sites of the enzymes. The intense physiological activity of important pesticides like DDVP, parathion and several others, is in fact related to their high phosphorylating potentiaP' A phosphoramidate of the structure (I) may apparently have enhanced phosphorylating potential by process of weakening of phosphorus-acyloxygen bond as shown and consequently the compound should be an interesting biotoxic agent. The situation obtained in (I) is comparable to P-XYZ system (ll)2) in which the electronegativity of Z, whether self or induced by electrophilic agents and Sp2) hybridised nature of Y tend to enhance the phosphorylating potential of the compound due to weakening of P-X bond. © 1979 Taylor & Francis Group, LLC.