Methyl 2-[2-(benzyloxycarbonylamino)propan-2-yl]-5-hydroxy-1-methyl-6-oxo1,6-dihydropyrimidine-4-carboxylate

The title pyrimidine derivative, C18H21N3O6, was obtained by the reaction of methyl 2-[2-(benzyloxycarbonyl) aminopropan2- yl]-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate with dimethyl sulfate in dimethyl sulfoxide. The molecule has a V-shaped structure, the phenyl and the pyrimidine rings making a dihedral angle of 43.1 (1)degrees. The methyl group substituting the pyrimidine ring deviates slightly from the ring mean-plane [C-N-C-C torsion angle = 5.49 (15)degrees], and the methyl ester substituent has a conformation suitable for the formation of an intramolecular O-H center dot center dot center dot O hydrogen bond with the hydroxyl functionality. In the crystal, molecules are linked into chains along the b axis by N-H center dot center dot center dot O hydrogen bonds.