ELEVATION OF RATIO OF URINARY N-ACETYLNEURAMINLACTOSE TO FREE SIALIC-ACID IN SOME ADVANCED CANCER-PATIENTS

被引：6

作者：

SHIMADA, I ^{[1
]}

SHOJI, M ^{[1
]}

FUTATSUYA, R ^{[1
]}

KATOH, T ^{[1
]}

KOMINATO, Y ^{[1
]}

SAKAMOTO, T ^{[1
]}

FUJIKURA, T ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC MED,DEPT SURG 2,TOYAMA 93001,JAPAN

来源：

JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 01期

关键词：

GASTROINTESTINAL CANCER; SIALIC ACID; SIALYLATED OLIGOSACCHARIDE; URINE;

D O I：

10.1007/BF01211370

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We estimated the levels of free sialic acid and sialylated oligosaccharides excreted in the urine of normal donors (n = 10) and patients with gastric cancer (n = 6) and colorectal cancer (n = 4). The total sialic acid level in cancer patients was similar to that in normal donors. However, the ratios of glycosidically bound sialic acids to free sialic acid were higher in some advanced cancer patients than in the normal donors. A major component of sialylated oligosaccharides was N-acetylneuraminyl alpha (2 --> 3) lactose. The elevation of the urinary ratio of this sialylated oligosaccharide to free sialic acid observed in some advanced cancer patients in this study may reflect the elevation of sialyltransferase activity in tumor tissues.

引用

页码：21 / 27

页数：7

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