MOLECULAR-BASIS OF THE LITTLE MOUSE PHENOTYPE AND IMPLICATIONS FOR CELL-TYPE-SPECIFIC GROWTH

被引：415

作者：

LIN, SC

LIN, CJR

GUKOVSKY, I

LUSIS, AJ

SAWCHENKO, PE

ROSENFELD, MG

机构：

[1] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA

[2] UNIV CALIF LOS ANGELES, DEPT MICROBIOL & MOLEC GENET, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, DEPT MED, LOS ANGELES, CA 90024 USA

[4] UNIV CALIF LOS ANGELES, INST MOLEC BIOL, LOS ANGELES, CA 90024 USA

[5] SALK INST BIOL STUDIES, NEURONAL STRUCT & FUNCT LAB, LA JOLLA, CA 92037 USA

来源：

NATURE | 1993年 / 364卷 / 6434期

关键词：

D O I：

10.1038/364208a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a different trophic factor. This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs.

引用

页码：208 / 213

页数：6

共 54 条

[1] CULTURE OF HORMONE-DEPENDENT FUNCTIONAL EPITHELIAL-CELLS FROM RAT THYROIDS [J].