COMBINED TREATMENT WITH PHOTODYNAMIC THERAPY AND CHEMOTHERAPY FOR ADVANCED CARDIAC CANCERS

In all, 144 patients with advanced cardiac cancers have been treated by photodynamic therapy (PDT), combined chemotherapy and chemotherapy alone from September 1982 to July 1990. A total of 5 mg kg-1 haematoporphyrin derivative (HpD) was intravenously given 48-72 h prior to PDT. The light source was an argon dye laser with an output beam of 630 nm. The irradiation time varied between 12 and 25 min with a fluence of 100-350 mW cm-2. The entire tumour was irradiated with a light dose of 100-250 J cm-2. The combination of UFT and mitomycin C was used as standard chemotherapy. There were 26 responders out of 55 patients (47.3%) in the group treated with PDT alone, 24 out of 41 (58.5%) in the PDT + chemotherapy group, and 24 out of 48 (50.0%) in the chemotherapy alone group. In the PDT + chemotherapy group 19.5% patients had complete remission, which was better than the other two groups (5.5%, 8.3%, p < 0.05). The following survey of all patients lasted from six months to seven years. The results suggest that a combination of PDT and chemotherapy may prove effective.