PHARMACOKINETIC PROPERTIES OF POLYETHYLENE-GLYCOL DERIVATIZED SUPEROXIDE-DISMUTASE

被引：53

作者：

BOCCU, E ^{[1
]}

VELO, GP ^{[1
]}

VERONESE, FM ^{[1
]}

机构：

[1] UNIV PADUA, INST PHARMACOL, I-37100 VERONA, ITALY

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1982年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0031-6989(82)80092-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of the extent of superoxide dismutase [SOD, EC 1.15.1.1] modification by PEG [polyethylene glycol] 1900 and 5000 on the rate of clearance was investigated. Modification of the enzyme deeply influences the permanence of SOD activity in the rat plasma. After i.v. injection the plasma half-life, which for the native SOD is of about 5 min, increases to 1.5, 3, 11 and 25 h for modified species with MW ranging from 37,000-121,000 daltons. The number of amino residues modified for each enzyme molecule and the structural stability of the molecule itself may be involved in the rate of clearance.

引用

页码：113 / 120

页数：8

共 20 条

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