PEPTICINNAMINS, NEW FARNESYL-PROTEIN TRANSFERASE INHIBITORS PRODUCED BY AN ACTINOMYCETE .2. STRUCTURAL ELUCIDATION OF PEPTICINNAMIN-E

被引：70
作者：
SHIOMI, K
YANG, H
INOKOSHI, J
VANDERPYL, D
NAKAGAWA, A
TAKESHIMA, H
OMURA, S
机构：
[1] KITASATO INST,BIOL FUNCT RES CTR,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN
[2] TEIKYO UNIV,SCH SCI & ENGN,UTSUNOMIYA,TOCHIGI 320,JAPAN
来源：
JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 02期
关键词：
D O I：
10.7164/antibiotics.46.229
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Structure of novel farnesyl transferase inhibitor, pepticinnamin E, is elucidated by NMR study. Pepticinnamin E is composed of five amino acids and o-pentenylcinnamic acid, having a molecular weight of 907. C-terminal glycylserine of the compounds is in the cyclized diketopiperazine form.
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页码：229 / 234
页数：6
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