Appraisal of In-Vitro and In-Vivo Antioxidant Activity Potential of the Ethanolic Leaf and Bark Extracts of Ficus dalhousiae Miq

被引：0

作者：

Nivedhitha, S. ^{[1
]}

Alagarsamy, V. ^{[2
]}

Chandrasekhar, K. B. ^{[3
]}

Gobinath, M. ^{[1
]}

机构：

[1] Ratnam Inst Pharm, Nellore 524346, Andhra Pradesh, India

[2] MNR Coll Pharm, Med Chem Res Lab, Sangareddy 502001, Telangana, India

[3] JNTUA, OTRI, Ananthapuramu 515001, Andhra Pradesh, India

来源：

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2015年 / 6卷 / 06期

关键词：

Ficus dalhousiae; Flavonoid; Total Phenolic; Antioxidant; Free radical scavenging;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The present study was aimed to investigate the antioxidant activity of ethanolic extract of the leaf and stem bark (EELFD, EEBFD) of Ficus dalhousiae Miq. Fam. Moraceae. The antioxidant activity of the extracts has been evaluated by using a variety of in vitro assays and an in vivo hepatoprotective model. The test extracts exhibited potential scavenging effects on DPPH, hydrogen peroxide and nitric oxide free radicals. In the in vivo hepatoprotective model the EELFD and EEBFD significantly increased the hepatic levels of reduced glutathione, antioxidant enzymes and decreased the lipid peroxidation. The free radical scavenging and antioxidant activities may be due to the presence of phenolic and flavonoid compounds of the EELFD and EEBFD. The result obtained in the present study justifies that Ficus dalhousiae is a potential source of natural antioxidant activity.

引用

页码：456 / 461

页数：6

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