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MAST-CELL DEGRANULATING PEPTIDE INDUCES THE EXPRESSION OF THE C-FOS PROTOONCOGENE IN HIPPOCAMPUS
被引:9
|作者:
SEQUIER, JM
[1
]
LAZDUNSKI, M
[1
]
机构:
[1] CNRS,INST PHARMACOL MOLEC & CELLULAIRE,UPR 411,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE
关键词:
Hippocampus;
Hybridization (in situ);
K[!sup]+[!/sup] channels;
Plasticity;
D O I:
10.1016/0014-2999(90)90607-8
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The intrahippocampal injection of the mast cell degranulating (MCD) peptide, a bee venom component acting on the K+ channel, results in the appearance of the proto-oncogene c-fos mRNA in the ipsi- and contralateral hippocampus of the treated animals without generating convulsions. This MCD-induced transcriptional event is discussed in terms of cellular plasticity since MCD peptide is known to induce long-term potentiation. © 1990.
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页码:179 / 181
页数:3
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