SYNTHESIS, CHARACTERIZATION AND ANTICANCER ACTIVITY OF COPPER(II), NICKEL(II) AND ZINC(II) COMPLEXES DERIVED FROM L-ARGININE

被引：0

作者：

CHEN, CH ^{[1
]}

WU, ZS ^{[1
]}

YEN, ZH ^{[1
]}

机构：

[1] HUAZHONG NORMAL UNIV,DEPT CHEM,HUAZHONG,PEOPLES R CHINA

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY | 1993年 / 23卷 / 10期

关键词：

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Copper(I), nickel(I) and zinc(I) complexes with the Schiff base derived from 2,4-dihydroxybenzaldehyde and L-arginine have been synthesized and characterized by elemental analyses, TG-DTA, IR, electronic spectra and conductivity measurements. The Schiff base ligand has been further characterized by (1)HNMR. The results suggest that the Schiff base acts as ONO tridental ligand. The electronic spectra of DNA - complexes and the fluoresence spectra of DNA - EthBr (ethidium bromide)-complexes indicate that the complexes of copper(I), nickel(I) and zinc( I) intercalate DNA. The test of anticancer activity in vivo shows that their cancer inhibition rates to EAC (Ehrlich ascites carcinoma) are 53.3%, 51.7% and 32.2%, respectively.

引用

页码：1725 / 1733

页数：9

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