MK-801 POTENTLY INHIBITS ALCOHOL-WITHDRAWAL SEIZURES IN RATS

被引：155
作者：
MORRISETT, RA
REZVANI, AH
OVERSTREET, D
JANOWSKY, DS
WILSON, WA
SWARTZWELDER, HS
机构：
[1] DUKE UNIV,MED CTR,DEPT MED NEUROL,DURHAM,NC 27710
[2] DUKE UNIV,MED CTR,DEPT PHARMACOL,DURHAM,NC 27710
[3] DUKE UNIV,MED CTR,DEPT PSYCHOL,DURHAM,NC 27710
[4] UNIV N CAROLINA,SCH MED,CTR ALCOHOL STUDIES,CHAPEL HILL,NC 27514
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 01期
关键词：
Alcohol withdrawal; Ethanol; Excitatory amino acid; MK-801; NMDA (N-methyl-D-aspartate); Seizure;
D O I：
10.1016/0014-2999(90)90138-V
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes. © 1990.
引用
收藏
页码：103 / 105
页数：3
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