ENDOTHELIN-1 EXACERBATES FOCAL CEREBRAL-ISCHEMIA WITHOUT EXERTING NEUROTOXIC ACTION IN-VITRO

被引:28
作者
NIKOLOV, R [1 ]
RAMI, A [1 ]
KRIEGLSTEIN, J [1 ]
机构
[1] PHILIPPS UNIV,INST PHARMAKOL & TOXIKOL,KETZERBACH 63,D-35037 MARBURG,GERMANY
来源
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1993年 / 248卷 / 02期
关键词
ENDOTHELIN-1; MIDDLE CEREBRAL ARTERY OCCLUSION; ISCHEMIA; HYPOXIA; CULTURED NEURONS; (MOUSE);
D O I
10.1016/0926-6917(93)90044-Q
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In a model of focal cerebral ischemia in mice, intracisternal injection of 5 and 10 pmol/mouse endothelin-1 significantly increased the infarcted surface area by 15.5% and by 23.5%, respectively. Endothelin-1 (0.01, 1, and 100 nmol/l) added to the primary neuronal cultures of chick embryo cerebral hemispheres for 1 h and 24 h did not influence the viability of the neurons or the protein content of the cultures. When applied simultaneously with 1 mmol/I sodium cyanide for 30 min, endothelin-I (0.01, 1, and 100 nM) did not modify the hypoxia-induced changes. The results show that exogenously applied endothelin-1 could exacerbate cerebral ischemia, probably due to its vasoconstrictive properties and not to a direct neurotoxic effect.
引用
收藏
页码:205 / 208
页数:4
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