INHIBITION OF POLIOVIRUS RNA-SYNTHESIS BY BREFELDIN-A

被引：160
作者：
MAYNELL, LA
KIRKEGAARD, K
KLYMKOWSKY, MW
机构：
[1] UNIV COLORADO,MOLEC CELLULAR & DEV BIOL,BOULDER,CO 80309
[2] UNIV COLORADO,HOWARD HUGHES MED INST,BOULDER,CO 80309
来源：
JOURNAL OF VIROLOGY | 1992年 / 66卷 / 04期
关键词：
D O I：
10.1128/JVI.66.4.1985-1994.1992
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Brefeldin A (BFA), a fungal metabolite that blocks transport of newly synthesized proteins from the endoplasmic reticulum, was found to inhibit poliovirus replication 10(5)- to 10(6)-fold. BFA does not inhibit entry of poliovirus into the cell or translation of viral RNA. Poliovirus RNA synthesis, however, is completely inhibited by BFA. A specific class of membranous vesicles, with which the poliovirus replication complex is physically associated, is known to proliferate in poliovirus-infected cells. BFA may inhibit poliovirus replication by preventing the formation of these vesicles.
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页码：1985 / 1994
页数：10
相关论文
共 46 条
[1]  
Ausubel FM., 1995, MOL REPROD DEV, V3rd edn, DOI DOI 10.1002/MRD.1080010210
[2]   POLIOVIRUS MUTANT THAT DOES NOT SELECTIVELY INHIBIT HOST-CELL PROTEIN-SYNTHESIS [J].
BERNSTEIN, HD ;
SONENBERG, N ;
BALTIMORE, D .
MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (11) :2913-2923
[3]   ASSOCIATION OF POLIOVIRAL PROTEINS OF THE P2-GENOMIC REGION WITH THE VIRAL REPLICATION COMPLEX AND VIRUS-INDUCED MEMBRANE SYNTHESIS AS VISUALIZED BY ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY AND AUTORADIOGRAPHY [J].
BIENZ, K ;
EGGER, D ;
PASAMONTES, L .
VIROLOGY, 1987, 160 (01) :220-226
[4]   KINETICS AND LOCATION OF POLIOVIRUS MACROMOLECULAR-SYNTHESIS IN CORRELATION TO VIRUS-INDUCED CYTOPATHOLOGY [J].
BIENZ, K ;
EGGER, D ;
RASSER, Y ;
BOSSART, W .
VIROLOGY, 1980, 100 (02) :390-399
[5]   STRUCTURAL ORGANIZATION OF POLIOVIRUS RNA REPLICATION IS MEDIATED BY VIRAL-PROTEINS OF THE P2 GENOMIC REGION [J].
BIENZ, K ;
EGGER, D ;
TROXLER, M ;
PASAMONTES, L .
JOURNAL OF VIROLOGY, 1990, 64 (03) :1156-1163
[6]   VIRUS REPLICATION, CYTOPATHOLOGY, AND LYSOSOMAL ENZYME RESPONSE OF MITOTIC AND INTERPHASE HEP-2 CELLS INFECTED WITH POLIOVIRUS [J].
BIENZ, K ;
EGGER, D ;
WOLFF, DA .
JOURNAL OF VIROLOGY, 1973, 11 (04) :565-574
[7]  
BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
[8]   PROTEOLYSIS OF THE P220 COMPONENT OF THE CAP-BINDING PROTEIN COMPLEX IS NOT SUFFICIENT FOR COMPLETE INHIBITION OF HOST-CELL PROTEIN-SYNTHESIS AFTER POLIOVIRUS INFECTION [J].
BONNEAU, AM ;
SONENBERG, N .
JOURNAL OF VIROLOGY, 1987, 61 (04) :986-991
[9]   ASSOCIATION OF POLIO-VIRAL RNA-POLYMERASE COMPLEX WITH PHOSPHOLIPID MEMBRANES [J].
BUTTERWORTH, BE ;
SHIMSHICK, EJ ;
YIN, FH .
JOURNAL OF VIROLOGY, 1976, 19 (02) :457-466
[10]   ROLE OF CYTOPLASMIC MEMBRANES IN POLIOVIRUS BIOSYNTHESIS [J].
CALIGUIRI, LA ;
TAMM, I .
VIROLOGY, 1970, 42 (01) :100-+
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