CLINICAL MANIFESTATIONS OF PRIMARY HERPES-SIMPLEX VIRUS TYPE-1 INFECTION IN A CLOSED COMMUNITY

被引：0

作者：

KUZUSHIMA, K ^{[1
]}

KIMURA, H ^{[1
]}

KINO, Y ^{[1
]}

KIDO, S ^{[1
]}

HANADA, N ^{[1
]}

SHIBATA, M ^{[1
]}

MORISHIMA, T ^{[1
]}

机构：

[1] CHEMO SERO THERAPEUT RES INST,KUMAMOTO,JAPAN

来源：

PEDIATRICS | 1991年 / 87卷 / 02期

关键词：

HERPES SIMPLEX VIRUS TYPE-1; GLYCOPROTEIN-B; MOLECULAR EPIDEMIOLOGY; DAY-CARE CENTER;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The clinical features and the molecular epidemiology of primary herpes simplex virus type 1 (HSV-1) infection among children younger than 3 years of age were investigated in day-care nursery. Serial sera were assayed for the anti-HSV-1 glycoprotein B antibody by enzyme-linked immunosorbent assay. Serologic examinations revealed 55 cases of primary HSV infection during the observation period. Fifty-one of them (93%) had typical herpetic gingivostomatitis, showing a high rate of clinically overt infection. Four outbreaks of herpetic gingivostomatitis were observed during the observation period. Forty-one children were infected with HSV-1 in the outbreaks. The rates of infection in the susceptible children were 81%, 73%, 78%, and 100%, respectively, in the four outbreaks. Restriction endonuclease analysis of DNA of isolated HSV revealed that only one strain of HSV-1 had been transmitted among children for a long period.

引用

页码：152 / 158

页数：7

共 37 条

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