H-1-NMR STUDIES ON THE SELF-ASSOCIATION OF CHLOROQUINE IN AQUEOUS-SOLUTION

被引：15

作者：

MARCHETTINI, N ^{[1
]}

VALENSIN, G ^{[1
]}

GAGGELLI, E ^{[1
]}

机构：

[1] UNIV BASILICATA,INST CHEM,I-85100 POTENZA,ITALY

来源：

BIOPHYSICAL CHEMISTRY | 1990年 / 36卷 / 01期

关键词：

!sup]1[!/sup]H-NMR; Chloroquine; Self-association;

D O I：

10.1016/0301-4622(90)85008-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concentration dependences of 1H-NMR chemical shifts and spin-lattice relaxation rates were measured for chloroquine in aqueous solution. The weak self-association constant was evaluated according to a dimerization equilibrium with the formation of self-stacked adducts (K̄d = 4.52 ± 0.68 1 mol-1). The motional correlation times were evaluated for the monomer and the dimer by measuring intramolecular dipolar cross-relaxation rates of aromatic vicinal protons (τcm = 0.06 ns and τcd = 0.26 ns). The geometry of the stacked dimer was elucidated by measuring intermolecular dipolar cross-relaxation rates and interpreted in terms of partial superposition of quinoline moieties. © 1990.

引用

页码：65 / 70

页数：6

共 25 条

[1] A REFINEMENT OF THE CRYSTAL AND MOLECULAR STRUCTURES OF NAPHTHALENE AND ANTHRACENE [J].