INTEGRATION OF EPSTEIN-BARR-VIRUS NEAR THE BREAKPOINT OF A TRANSLOCATION 11-19 IN A BURKITTS-LYMPHOMA CELL-LINE

被引:18
作者
WOLF, J
PAWLITA, M
JOX, A
KOHLS, S
BARTNITZKE, S
DIEHL, V
BULLERDIEK, J
机构
[1] UNIV BREMEN,CTR HUMAN GENET & GENET COUNSELLING,W-2800 BREMEN 33,GERMANY
[2] UNIV COLOGNE,DEPT INTERNAL MED 1,W-5000 COLOGNE 41,GERMANY
[3] GERMAN CANC RES CTR,INST VIRUS RES,W-6900 HEIDELBERG 1,GERMANY
关键词
D O I
10.1016/0165-4608(93)90158-I
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The physical state of Epstein Barr virus (EBV) DNA was analyzed in the Burkitt's lymphoma (BL) cell line BL60 and in the autologous EBV-immortalized lymphoblastoid cell line (LCL) IARC 277 by Gardella gel analysis, Southern blotting, and nonradioactive in situ hybridization to metaphase chromosomes. Although only episomal viral DNA was detected in the LCL, the 6-12 copies of EBV DNA in the BL cell line are integrated in one site of the host cell genome. The integration site is located near the breakpoint of a translocation 11;19 which is present in this cell line in addition to the BL-specific t(8;22).
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收藏
页码:90 / 94
页数:5
相关论文
共 33 条
  • [1] EVIDENCE FOR INTEGRATED EBV GENOMES IN RAJI CELLULAR DNA
    ANVRET, M
    KARLSSON, A
    BJURSELL, G
    [J]. NUCLEIC ACIDS RESEARCH, 1984, 12 (02) : 1149 - 1161
  • [2] DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME
    BAER, R
    BANKIER, AT
    BIGGIN, MD
    DEININGER, PL
    FARRELL, PJ
    GIBSON, TJ
    HATFULL, G
    HUDSON, GS
    SATCHWELL, SC
    SEGUIN, C
    TUFFNELL, PS
    BARRELL, BG
    [J]. NATURE, 1984, 310 (5974) : 207 - 211
  • [3] ABERRATIONS OF CHROMOSOME-19 - DO THEY CHARACTERIZE A SUBTYPE OF BENIGN THYROID ADENOMAS
    BELGE, G
    THODE, B
    BULLERDIEK, J
    BARTNITZKE, S
    [J]. CANCER GENETICS AND CYTOGENETICS, 1992, 60 (01) : 23 - 26
  • [4] BISHOP JM, 1981, CELL, V23, P5
  • [5] TRANSLOCATION T(11-19)(Q21-P13.1) AS THE SOLE CHROMOSOME ABNORMALITY IN A CYSTADENOLYMPHOMA (WARTHINS TUMOR) OF THE PAROTID-GLAND
    BULLERDIEK, J
    HAUBRICH, J
    MEYER, K
    BARTNITZKE, S
    [J]. CANCER GENETICS AND CYTOGENETICS, 1988, 35 (01) : 129 - 132
  • [6] INTEGRATION OF PAPILLOMAVIRUS DNA NEAR MYC GENES IN GENITAL CARCINOMAS AND ITS CONSEQUENCES FOR PROTOONCOGENE EXPRESSION
    COUTURIER, J
    SASTREGARAU, X
    SCHNEIDERMAUNOURY, S
    LABIB, A
    ORTH, G
    [J]. JOURNAL OF VIROLOGY, 1991, 65 (08) : 4534 - 4538
  • [7] DAMBAUGH T, 1986, EPSTEINBARR VIRUS RE, P13
  • [8] FEINBERG AP, 1984, ANAL BIOCHEM, V137, P266
  • [9] DETECTION OF CIRCULAR AND LINEAR HERPESVIRUS DNA-MOLECULES IN MAMMALIAN-CELLS BY GEL-ELECTROPHORESIS
    GARDELLA, T
    MEDVECZKY, P
    SAIRENJI, T
    MULDER, C
    [J]. JOURNAL OF VIROLOGY, 1984, 50 (01) : 248 - 254
  • [10] DIFFERENT LOCALIZATION OF EPSTEIN-BARR-VIRUS GENOME IN 2 SUBCLONES OF THE BURKITT-LYMPHOMA CELL-LINE NAMALWA
    GARGANO, S
    CAPOROSSI, D
    GUALANDI, G
    CALEF, E
    [J]. GENES CHROMOSOMES & CANCER, 1992, 4 (03) : 205 - 210