HETEROGENEITY OF ENDOTHELIN SARAFOTOXIN RECEPTORS MEDIATING CONTRACTION OF THE HUMAN ISOLATED SAPHENOUS-VEIN

被引：38

作者：

BAX, WA ^{[1
]}

BOS, E ^{[1
]}

SAXENA, PR ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,CTR THORAX,DEPT THORAC SURG,3000 DR ROTTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 239卷 / 1-3期

关键词：

ENDOTHELIN-1; SARAFOTOXIN-S6B; BQ-123; ENDOTHELIN ET(A) RECEPTOR; SAPHENOUS VEIN (HUMAN);

D O I：

10.1016/0014-2999(93)91010-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effect of the ET(A) receptor antagonist, BQ-123 (0.1 and 1 muM), on contraction of the human isolated saphenous vein induced by endothelin-1 or sarafotoxin S6b. Contraction in response to endothelin-1 was not affected by BQ-123. In contrast, BQ-123 biphasically attenuated the contractions due to sarafotoxin S6b. These data indicate that (i) endothelin-1 induces contractions of the human saphenous vein via a non-ET(A) receptor and (ii) contractions in response to sarafotoxin S6b are mediated in part via a receptor different from the receptor mediating contraction due to endothelin-1.

引用

页码：267 / 268

页数：2

共 8 条

[1] IDENTIFICATION OF A DOMAIN OF ET(A) RECEPTOR REQUIRED FOR LIGAND-BINDING [J].