CONVERSION OF ARTEMISININ TO ARTEMISITENE

被引：50

作者：

ELFERALY, FS ^{[1
]}

AYALP, A ^{[1
]}

ALYAHYA, MA ^{[1
]}

MCPHAIL, DR ^{[1
]}

MCPHAIL, AT ^{[1
]}

机构：

[1] DUKE UNIV,PAUL M GROSS CHEM LAB,DEPT CHEM,DURHAM,NC 27706

来源：

JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 01期

关键词：

D O I：

10.1021/np50067a008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Artemisinin [1], a potent antimalarial sesquiterpene endoperoxide, was converted via a photochemical route to its dehydro analogue, artemisitene [5]. The structure and stereochemistry of the hydroperoxide intermediate 4, produced by the action of1O2 on the enol ether 3, were established by X-ray crystallographic analysis. © 1990, American Chemical Society. All rights reserved.

引用

页码：66 / 71

页数：6

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