P-31 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPIC OBSERVATION OF THE INTRACELLULAR TRANSFORMATIONS OF ONCOSTATIC CYCLOPHOSPHAMIDE METABOLITES

被引:61
作者
BOYD, VL
ROBBINS, JD
EGAN, W
LUDEMAN, SM
机构
[1] CTR DRUGS & BIOL,DIV BIOCHEM & BIOPHYS,BIOPHYS LAB,BETHESDA,MD 20892
[2] CATHOLIC UNIV AMER,DEPT CHEM,WASHINGTON,DC 20064
[3] TRINITY COLL,DEPT CHEM,WASHINGTON,DC 20017
关键词
D O I
10.1021/jm00157a015
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1206 / 1210
页数:5
相关论文
共 30 条
[1]   ENZYMATIC TOXICOGENATION OF ACTIVATED CYCLOPHOSPHAMIDE BY 3'-5' EXONUCLEASES [J].
BIELICKI, L ;
VOELCKER, G ;
HOHORST, HJ .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1983, 105 (01) :27-29
[2]  
BROCK N, 1976, CANCER TREAT REP, V60, P301
[3]  
COLVIN M, 1976, CANCER RES, V36, P1121
[4]  
DOMEYER BE, 1980, CANCER RES, V40, P174
[5]   INHIBITION BY CYANAMIDE OF 4-HYDROXYCYCLOPHOSPHAMIDE-ALDOPHOSPHAMIDE OXIDATION TO CARBOXYPHOSPHAMIDE [J].
DOMEYER, BE ;
SLADEK, NE .
BIOCHEMICAL PHARMACOLOGY, 1981, 30 (15) :2065-2073
[6]  
DRAEGER U, 1976, CANCER TREAT REP, V60, P355
[7]  
EGAN W, NMR SPECTROSCOPY CEL
[8]   P-31 NMR INVESTIGATIONS OF PHOSPHORAMIDE MUSTARD - EVALUATION OF PH CONTROL OVER THE RATE OF INTRA-MOLECULAR CYCLIZATION TO AN AZIRIDINIUM ION AND THE HYDROLYSIS OF THIS REACTIVE ALKYLATOR [J].
ENGLE, TW ;
ZON, G ;
EGAN, W .
JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (08) :897-898
[9]  
FENSELAU C, 1977, CANCER RES, V37, P2538
[10]   NMR-STUDIES OF PERFUSED CELLS [J].
FOXALL, DL ;
COHEN, JS .
JOURNAL OF MAGNETIC RESONANCE, 1983, 52 (02) :346-349