ONLINE TRACE ENRICHMENT OF MIFENTIDINE IN PLASMA USING COLUMN-SWITCHING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：5
作者：
JANG, WC
LEE, HS
机构：
[1] Screening & Toxicology Research Center, Korea Research Institute of Chemical Technology, Daedeog Danji, Taejeon, 305-606
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 06期
关键词：
D O I：
10.1080/10826079408013770
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The purpose of this study was to develop for the determination of mifentidine, a new long-acting histamine H-2 receptor antagonist,in plasma using a column-switching HPLC with a ultraviolet (UV) detection. Changing the pH influenced the species equilibria of mifentidine and these were well monitored and quantitated. This method showed a excellent precision with good sensitivity and speed, and a detection limit of 10 ng/mL. The total analysis time per sample was less than 20 min and mean coefficients of variation for intra- and inter- assay were both less than 3 %. The method has been successfully applied to plasma samples from rats receiving oral administration of mifentidine.
引用
收藏
页码：1375 / 1384
页数：10
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