INVIVO PHOSPHOLIPID MODIFICATION INDUCES CHANGES IN MICROSOMAL DELTA-5-DESATURASE ACTIVITY

被引：19
作者：
LEIKIN, AI
BRENNER, RR
机构：
[1] Institute de Investigations Bioquímicas de La Plata (INIBIOLP), CONICET-UNLP, Facultad de Ciencias Médicas, La Plata
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1165卷 / 02期
关键词：
MICROSOMAL MEMBRANE; DELTA-5; DESATURASE; PHOSPHOLIPID COMPOSITION; ARACHIDONIC ACID; FLUIDITY; (RAT LIVER);
D O I：
10.1016/0005-2760(92)90186-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The phospholipid composition of rat-liver microsomes was modified by feeding weaning rats a choline-free diet. After 21 days, the phosphatidylcholine content decreascd with a concomitant increment of phosphatidylserine and cholesterol. The bulk fluidity of the membrane decreased. Under these conditions, the DELTA5-desaturase activity was diminished as well as the arachidonic-acid content of the membrane lipids.
引用
收藏
页码：189 / 193
页数：5
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