DNA DAMAGE BY OXYGEN-DERIVED SPECIES - ITS MECHANISM AND MEASUREMENT IN MAMMALIAN SYSTEMS

被引：1320
作者：
HALLIWELL, B [1 ]
ARUOMA, OI [1 ]
机构：
[1] UNIV LONDON KINGS COLL, DEPT BIOCHEM, LONDON WC2R 2LS, ENGLAND
来源：
FEBS LETTERS | 1991年 / 281卷 / 1-2期
关键词：
DNA; MUTATION; OXYGEN RADICAL; HYDROXYL RADICAL; OXIDATIVE STRESS;
D O I：
10.1016/0014-5793(91)80347-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When cells are exposed to oxidative stress, DNA damage frequently occurs. The molecular mechanisms causing this damage may include activation of nucleases and direct reaction of hydroxyl radicals with the DNA. Several oxygen-derived species can attack DNA, producing distinctive patterns of chemical modification. Observation of these patterns and measurement of some of the products formed has been used to determine the role of different oxygen-derived species in DNA cleavage reactions, to assess the extent of oxidative damage to DNA in vivo and to investigate the mechanism of DNA damage by ionizing radiation and chemical carcinogens.
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页码：9 / 19
页数：11
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